chemokine (C-C motif) ligand 2
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General Information
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Gene Summary
Entrez Gene Name:
Synonyms:
Ccl12, CHEMOKINE C-C MOTIF LIGAND 2, GDCF-2, HC11, HSMCR30, JE, LOC100048556, MCAF, MCP-1, MCP-5, MGC9434, Monocyte Chemoattractant Protein 5, Scya12, SCYA2, Small inducible cytokine A12, SMC-CF
Entrez Gene Description:
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq]
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Chromosomal Location Information
View chrosomal location map
(Link will open the map viewer in NCBI website.)
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Homology Information
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Mutation Information
Protein Domain Supporting Evidence Disease Association Supporting Evidence Show more Unspecified Gene Deletion rheumatoid arthritis Show Findings (2) Unspecified Gene Deletion asthma Show Findings (2) Unspecified Gene Deletion atopic dermatitis Show Findings (2) -
Protein Family, Domain
Protein Family, Domain:
Protein Domain Supporting Evidence carboxy terminal domain Show Findings (1) chemokine Show Findings (1) cytokine Show Findings (1) signal transducer Show Findings (1) -
Location Information
Subcellular Location:
axons, cell body, cell surface, Cytoplasm, Extracellular Space, Golgi Apparatus, Golgi stacks, granules, intracellular space, plasma, trans Golgi network
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Bibliography
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Top Reading List for CCL2
Top List of References:
- Genetic Polymorphisms in the Cytokine and Chemokine System: Their Possible Importance in Allogeneic Stem Cell Transplantation. Loeffler J, Ok M, Morton OC, Mezger M, Einsele H. Curr Top Microbiol Immunol. 2010 Apr 14. [Epub ahead of print] PMID: 20397074 [PubMed - as supplied by publisher]
- Multiple roles of chemokine (C-C motif) ligand 2 in promoting prostate cancer growth. Zhang J, Lu Y, Pienta KJ. J Natl Cancer Inst. 2010 Apr 21;102(8):522-8. Epub 2010 Mar 16. Review. PMID: 20233997 [PubMed - indexed for MEDLINE]
- Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD). Ramkumar HL, Zhang J, Chan CC. Prog Retin Eye Res. 2010 May;29(3):169-90. Epub 2010 Mar 3. PMID: 20206286 [PubMed - in process]
- Mechanisms of mononuclear phagocyte recruitment in Alzheimer's disease. Hickman SE, El Khoury J. CNS Neurol Disord Drug Targets. 2010 Apr;9(2):168-73. PMID: 20205643 [PubMed - in process]
- Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. Gao YJ, Ji RR. Pharmacol Ther. 2010 Apr;126(1):56-68. Epub 2010 Feb 1. PMID: 20117131 [PubMed - in process]Free PMC ArticleFree text
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Supporting Literature
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Recently Added Findings
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Pathway/Network Information
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Canonical Pathway
Pathway Group Pathway Category Top Functions and Diseases Show moreShow less ATM Signaling Signaling Pathway Cell Cycle Regulation, Celluar Stress and Injury Cell Cycle; DNA Replication, Recombination, and Repair; Cell Death Cell Cycle: G2/M DNA Damage Checkpoint Regulation Signaling Pathway Cancer, Disease-Specific Pathways Cell Cycle; Cell Death; Cancer Hereditary Breast Cancer Signaling Signaling Pathway Cancer, Disease-Specific Pathways DNA Replication, Recombination, and Repair; Cell Cycle; Cancer Hereditary Breast Cancer Signaling Signaling Pathway Cancer, Disease-Specific Pathways DNA Replication, Recombination, and Repair; Cell Cycle; Cancer Hereditary Breast Cancer Signaling Signaling Pathway Cancer, Disease-Specific Pathways DNA Replication, Recombination, and Repair; Cell Cycle; Cancer -
Local Neighborhood
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Biological Information
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Disease Information
Positive (78)
infection, metastasis, asthma, arthritis, endometriosis, rheumatoid arthritis, Alzheimer's disease, bipolar affective disorder, breast cancer, colorectal cancer, fibrosis, hypotension, obliterative bronchiolitis, restenosis, tuberculosis, Ebola hemorrhagic fever, HIV encephalopathy, HIV infection, albuminuria, allergy, autoimmune disease, cancer, chronic obstructive pulmonary disease, congenital obstructive nephropathy, demyelination, essential hypertension, experimental autoimmune myocarditis, infectious disorder, major depression, mild cognitive impairment, multiple organ failure, multiple sclerosis, myalgia, neoplasia, osteoarthritis, ovarian cancer, parvovirus arthritis, pneumococcal pneumonia, severe combined immunodeficiency, spina bifida, systemic lupus erythematosus
Negative (5)
endometriosis, cancer, chronic hepatitis C, fibrosis, hepatocellular carcinoma, liver cancer, neoplasia
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Molecular Process Information
activation of (67)
MAPK3, MAPK1, Erk1/2, CCR2, MAPK14, MAPK11, MAPK8, NFkB, pi3k, AKT1, CDC42, Gpcr, ITGB2, MMP1 (includes EG:4312), Rac, STAT3
expression of (64)
"ICAM1, IL6, BIRC5, FASLG, IL4, MAP1LC3B, MMP1 (includes EG:4312), MMP9, CCL5, Collagen, IL13, IL1B, MMP2, TIMP1, TNF, ACTG2 (includes EG:72), CCL1, CCL11, CCL13, CD40, CD40LG, CXCL10, CXCL3, FAS, HDC, IFNG, IL10, IL1A, IL8, ITGA1, PTGDS, TGFB1, p70_s6k "
production of (23)
"Il12, IL10, TNF, IFNG, IL1B, IL2, IL4, IL6 "
release of (21)
"IL6, MMP9, arachidonic acid, leukotriene C4, Cytokine, F3, TNF, enzyme, nitric oxide, superoxide "
phosphorylation of (15)
"Akt, MAPK3, Erk1/2, CCR2, Erk, HIST2H3C, MAPK14, PAK1, SRC, amino acids "
activity of (13)
"MMP14, PTK2B, AP-1, Calpain, Chemokine, Erk1/2, MAPK14, MAPK8, Mtorc1, NFkB "
secretion of (12)
"IL6, MMP1 (includes EG:4312), CCL2, CCL7, COLLAGEN TYPE I, CXCL2, CXCL3, IL17A (includes EG:3605), TIMP1, TNF "
binding of (11)
"CCR2, GRIN2A, IL8, CCR5, DLG4, LRP1, ADRBK1, ARRB1, ENPP2, ITGA4, ITGB1, Il8 Receptor, NOS1 "
localization of (11)
"CLDN5, OCLN, MAP1LC3B, MMP14 "
accumulation of (10)
"F3, IL12A, IL12B, inositol phosphate "
flux of (9)
"calcium, Ca2+ "
internalization of (6)
"CLDN5, OCLN, CCR2, Ccr "
quantity of (6)
"Ca2+, calcium, cyclic AMP, lipid, phospholipid "
antagonization of (4)
"CCR2, Il8 Receptor "
clustering of (4)
"ITGAL, Integrin, MMP14 "
distribution of (3)
"CCR2, CCR5, FPR1 "
mobilization of (3)
"calcium, Ca2+ "
polymerization of (3)
"F Actin, Actin "
co-localization of (2)
"CAV1, CLDN5, OCLN "
concentration of (2)
"cholesterol, triacylglycerol "
conformational modification of (2)
"CCR2, CXCR4 "
dimerization of (2)
MMP14
formation of (2)
"CCR2, CXCR4 "
function of (2)
"Integrin, MMP14 "
generation of (2)
reactive oxygen species
signaling by (2)
protein
stimulation of (2)
Mek
synthesis of (2)
cyclic AMP
binding affinity of (1)
ITGAL
cell rounding of (1)
F Actin
conformation of (1)
ITGAL
down-modulation of (1)
CCR2
homeostasis of (1)
Ca2+
influx of (1)
calcium
translocation of (1)
ADRBK1
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Cellular Process Information
chemotaxis of (88)
monocytes, leukemia cell lines, cells, T lymphocytes, dendritic cells, endothelial cells, leukocytes, neutrophils, PBMC cells, astrocytes, basophils, bone marrow cells, bone marrow-derived macrophages, eosinophils, lymphoma cell lines, macrophage cancer cell lines, macrophages, memory T lymphocytes, mononuclear cells, myeloma cell lines, osteoclasts, peripheral blood monocytes
migration of (55)
"leukemia cell lines, macrophages, T lymphocytes, monocytes, leukocytes, lymphocytes, neutrophils, cells, endothelial cells, eosinophils, PBMC cells, dendritic cells, fibrocytes, monocyte-derived macrophages, peritoneal macrophages, smooth muscle cells "
recruitment of (35)
"monocytes, leukocytes, neutrophils, T lymphocytes, inflammatory leukocytes, cells, dendritic cells, macrophages, mononuclear cells, Kupffer cells, lymphocytes, monocyte-derived macrophages, osteoclasts, synovial cells, synovial fibroblasts "
expression in (19)
"renal tubular epithelial cells, prostate cancer cell lines, peripheral blood monocytes "
activation of (16)
"monocytes, T lymphocytes, macrophages, neutrophils, cells, dendritic cells, osteoclasts, synovial cells, synovial fibroblasts "
adhesion of (15)
"cells, endothelial cells, leukocytes, lymphoma cell lines, peripheral blood lymphocytes, endothelial cell lines, glomerular cells, mononuclear cells, neutrophils "
differentiation of (11)
"peripheral blood mononuclear leukocytes, T lymphocytes, fibroblasts, monocytes, multinucleated cells, myofibroblasts, osteoclasts, bone marrow-derived mononuclear cells, osteoclast-like cells "
chemoattraction of (9)
"monocytes, eosinophils, leukocytes, lymphocytes, macrophages, natural killer T lymphocytes "
cell movement of (7)
"natural killer cells, cells "
formation of (6)
"endothelial cells, foreign body giant cell, multinucleated cells, osteoclasts, uropod "
proliferation of (6)
"smooth muscle cells, brain cancer cell lines, carcinoma cell lines, endothelial cells, leukocytes, lung cancer cell lines "
quantity of (6)
"macrophages, lymphocytes, osteoclasts, smooth muscle cells "
trafficking of (5)
leukocytes
co-stimulation of (4)
"T lymphocytes, monocytes "
infiltration by (4)
"lymphocytes, macrophages, monocytes, neutrophils "
mobilization of (4)
"cells, myeloid progenitor cells, neutrophils, stem cells "
production in (4)
monocytes
survival of (4)
prostate cancer cell lines
accumulation of (3)
"basophils, leukocytes, macrophages "
binding of (3)
"endothelial cells, lymphoma cell lines, monocytes, neutrophils "
cell death of (3)
prostate cancer cell lines
elimination of (3)
Leishmania major
excitation of (3)
cells
influx of (3)
"monocytes, myeloid cells, neutrophils "
response of (3)
"dendritic cells, leukocytes "
shape change of (3)
basophils
transmigration of (3)
"dendritic cells, monocytes "
activity of (2)
monocytes
apoptosis of (2)
"endometrial stromal cells, leukocytes "
attraction of (2)
"macrophages, neutrophils "
chemotaxis by (2)
"leukemia cell lines, neutrophils "
clustering in (2)
T lymphocytes
cytotoxicity of (2)
"cells, natural killer cells "
desensitization of (2)
"leukocytes, monocytes "
fusion of (2)
"cells, osteoclasts "
generation in (2)
phagocytes
growth of (2)
"myeloid progenitor cells, tumor cells "
homing of (2)
"cells, leukocytes "
internalization in (2)
endothelial cells
osteoclastogenesis of (2)
osteoclasts
phosphorylation in (2)
"T lymphocytes, monocytes "
polarization of (2)
"cells, dendritic cells "
respiratory burst of (2)
monocytes
signaling in (2)
cells
stimulation of (2)
"lymphocytes, monocytes "
Th1/Th2 polarization of (1)
leukocytes
activation by (1)
eosinophils
adherence of (1)
leukocytes
cell viability of (1)
prostate cancer cell lines
chemokinesis of (1)
T lymphocytes
clearance of (1)
Streptococcus pneumoniae
compartmentalization of (1)
cells
death of (1)
bacteria
degranulation of (1)
leukocytes
electrical resistance of (1)
endothelial cells
entrance of (1)
lymphocytes
interaction of (1)
"T lymphocytes, antigen presenting cells "
invasion by (1)
eosinophils
invasion of (1)
tumor-infiltrating lymphocytes
mobilization in (1)
monocytes
penetration of (1)
monocytes
viral entry of (1)
cells
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Organismal Process Information
formation of (6)
blood vessel, endothelial tube, atherosclerotic lesion, thrombus
angiogenesis of (4)
blood vessel
infiltration in (4)
"ear, rat "
remodeling of (4)
tissue
angiogenesis in (3)
"mouse, aorta "
elimination of (3)
Leishmania major
inflammation of (3)
"airway, animal, mouse "
insulin resistance of (3)
mouse
recruitment in (3)
"organism, airway "
survival of (3)
mouse
accumulation in (2)
"heart, inflammation site "
activation in (2)
"immune system, nervous system "
attraction in (2)
site of infection
immune response in (2)
organism
inflammatory response in (2)
organism
activation of (1)
tissue
cell movement in (1)
mammalia
clearance of (1)
Streptococcus pneumoniae
compartmentalization in (1)
lymphoid organ
death of (1)
bacteria
desensitization in (1)
blood
dysfunction of (1)
vascular system
entrance of (1)
HIV
fever in (1)
organism
fever of (1)
mammalia
formation in (1)
mammalia
fusion of (1)
HIV
growth of (1)
micrometastases
homing in (1)
mammalia
host defense in (1)
organism
infectivity of (1)
HIV-1
injury of (1)
lung
instability of (1)
vascular system
invasion of (1)
tissue
lymphorganogenesis in (1)
mammalia
migration in (1)
mouse
organization in (1)
synovial membrane
organization of (1)
lymphoid tissue
osteoclastogenesis in (1)
organism
repair of (1)
endothelial tissue
replication of (1)
virus
shock response in (1)
organism
thickness of (1)
vascular tissue
trafficking in (1)
lymphoid organ
viral entry by (1)
HIV
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Biological Interactions
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Protein-protein Interaction
Positive (80)
CCR2, Vv35, CCBP2, CCR5, CCR3, CCRL1, DARC, CCL2, CCR1, CCL5, CD44, COL18A1, CXCR4, Gpcr, IL8RB, VCAN, Vckbp1, hvCkbp
Negative (7)
CCRL1, CD44, IGFBP7, MMP2, SELPLG, Vv35
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Protein-nucleic Acid Interaction
Positive (11)
NR3C1, KDM1A, Histone h3, IRF3, RELA, ZNF217
Negative (3)
Estrogen receptor, NR3C2, Rar
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Protein-cell Tissue Interaction
Positive (17)
monocytes, leukemia cell lines, endothelial cells, bone matrix, renal tubular epithelial cells, smooth muscle cells
Negative (1)
macrophages
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Protein-microorganism Interaction
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Gene Regulation
expression regulated by (654)
"TNF, lipopolysaccharide, IL1B, IFNG, CP-55940, NFkB, IL6, prostaglandin E2, IL1A, FN1, HGF, F2, PD98059, integrin binding domain, CD40LG, FAS, Ifn gamma, PD 168393, PGF, TAT, beta-estradiol, cerivastatin, negative pressure, nickel chloride, retinoic acid, BMP7, NR3C1, PLG, U0126, binding, endometrial stromal cells, infection, protein fragment, IKBKB, IL13, IL6R, Il1, KLF2, LPL, NfkB1-RelA, Rlp, TGFA, idiopathic pulmonary fibrosis, phytohemagglutinin, rosiglitazone, 15-deoxy-delta-12,14 -PGJ 2, APP, CD40, CNR2, Immunoglobulin, L-homocysteine, SB203580, SR 144528, Sb202190, TNFRSF1A, benzyloxycarbonyl-Leu-Leu-Leu aldehyde, cycloheximide, lymphocytic choriomeningitis virus, mechanical strain, peptidoglycan, phorbol myristate acetate, shear stress, steroid, wortmannin, EGFR, IFNB1, IL1RN, JUN, Jnk, KITLG, LDL, LY294002, N-formyl-Met-Leu-Phe, NFKBIA, PDGF-BB, PLP1, RELA, Rac, STAT3, TNFSF12, VEGFA, [D-Ala2,N-Me-Phe4,Gly5-ol]-Enkephalin, adhesion, amphotericin B, apoptosis, dexamethasone, neutrophils, poly rI:rC-RNA, progesterone, 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine, ADCYAP1, ADIPOQ, AGI-1067, AIMP1, Bacillus anthracis Sterne strain 7702, C5, CAMP, CCBP2, CCL11, CCL3, CCL4, CCL5, COL1A1, CXCL12, D609, DARC, DNA fragment, E. coli lipopolysaccharide, Ebola virus, F. tularensis novicida U112, FOS, FXYD5, Fc epsilon r1, Francisella tularensis live vaccine strain lipopolysaccharide, GJA1, GSK3B, Gliadin, HAEC cells, HMGB1 (includes EG:3146), I Kappa B Alpha, IDN-1529, IFNA2, ITGB1, JAK1, Jnk-binding domain, LEF, Listeria monocytogenes 10403S, NFKB1, NOS3, NfkB-RelA, PF4, PLA2G10, PPARG, PROC, Pertussis toxin, RET, RGS10, S-nitrosoglutathione, SARS coronavirus HKU-39849, SMARCA4, SP600125, STAT4, Salmonella, Sendai virus, Stx2, TGFB1, TLR3, TNFSF11, VIP, camobucol, cilostazol, corticosteroid, diphenyleneiodonium, estrogen, experimentally-induced asthma, heavy metal, histamine, hyaluronic acid, hypoxia, ilomastat, isopentenyl diphosphate, lactacystin, maturation, n-3 fatty acids, piceatannol, poly-L-lysine, probucol, protein-protein complex, simvastatin, troglitazone, zVAD-FMK, 1,2-dipalmitoylphosphatidylcholine, 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine, 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphorylcholine, 2-(2-[4-phenoxy-2-propylphenoxy]ethyl)indole-5-acetic acid, 5-N-ethylcarboxamido adenosine, 5/6-nephrectomy, ADORA1, AG490, AGT, AKT1, ALB, AP-1, ATP-gamma-S, Angiotensin II receptor type 1, B lymphocytes, BAY 11-7085, Bacillus anthracis, C3, CD28, CDKN1A, CHUK, COL18A1, CSF2, CXCL3, CXCR4, Cd3, Collagen Type IV, D-glucose, D-homocysteine, DEFENSIN, E-64c, EGR1, ERBB4, Enterotoxin B, Erk1/2, Esat6, F2R, F2RL1, FASLG, FCGR2A, Francisella tularensis subsp. holarctica LVS, Gd3+, Gpcr, Hcg (chorionic gonadotropin complex), Ht29 cells, IFI16, IL10, IL17F, IL18, IL3, IL4, IL9, INSR, IRF3, Iberiotoxin, Ifn, IgE, Igg, Insulin, KDM1A, L-alpha-lysophosphatidylcholine, palmitoyl, L-cysteine, L-homocystine, L-methionine, LEP, LIPG, LPNA, Laminin, MAP2K4, MAP2K6, MAPK1, MAPK14, MAPK8, MAPKAPK2, MEOX2, MYD88, N-Ac-Leu-Leu-norleucinal, N-nitro-L-arginine methyl ester, NFKBIB, NFKBIE, NLR, Nfat, OLR1, PAGA, PBMC cells, PP2/AG1879 tyrosine kinase inhibitor, PRTN3, PXO1 122, Pdgf protein, Pseudomonas aeruginosa, RETN, Rabies virus strain SPBNGAS-GAS, Raf, S-nitroso-N-acetyl-DL-penicillamine, S-nitroso-N-acetylpenicillamine, S100A8, S100A9, SELP, SELPLG, SERPINA1, SMAD3, SPP1, STAT1, STAT6, Streptococcus sp. group G, TLR2, TNFRSF12A, TRADD, TRAF6, TYROBP, Tc52, Tlr, Tnf, UCN2, VP35, YM 529, YOPH, ZNF217, alprazolam, apigenin, apocynin, atorvastatin, bisphenol A, camptothecin, carbaprostacyclin, cardiolipin, cardiotoxin, colchicine, cyclosporin A, cytochalasin D, decidualization, dendritic cells, dioleoyl phosphatidylethanolamine, disruption, edaravone, encephalomyocarditis virus, endometriosis, endothelial cells, entrance, epoxyquinol B, ethanol, geranylgeranyl pyrophosphate, glucocorticoid, homocysteine, human respiratory syncytial virus A2, hydrocortisone, hydrogen peroxide, hydroxyurea, inflammation, injury, medroxyprogesterone acetate, mevalonic acid, migration, monocyte-derived dendritic cells, myeloid dendritic cells, nonylphenol, omega-6 polyunsaturated fatty acid, omega-9 fatty acid, omega-N-methylarginine, orlistat, oxypurinol, peripheral blood monocytes, phagocytosis, phorbol esters, pirinixic acid, polyinosinic acid, prednisolone, respiratory syncytial virus, resveratrol, salsalate, silica, stimulation, stromal cells, tosylphenylalanyl chloromethyl ketone, unmethylated CpG ODN, wounding, zidovudine "
production regulated by (227)
"PRTN3, homocysteine, Ebola virus, poly rI:rC-RNA, IL1B, IL2, IL15, CAMP, F2, Igg, Marburg virus, TNF, Bacillus anthracis, C3, C5, SB203580, TNFSF12, IL10, IL1A, activation, amphotericin B, leukotriene D4, CD40LG, CpG ODN 1826, Cytokine, E. coli lipopolysaccharide, FK 156, FK 565, Francisella tularensis live vaccine strain lipopolysaccharide, IL6R, N-acetylmuramyl-L-alanyl-D-isoglutamine, PD98059, PTAFR, RNASE2, S-(2, 3-bispalmitoyloxypropyl)-cysteine-GDPKHPKSF, TLR4, Tlr, Tnfsf5, U0126, U73122, advanced glycation endproducts-bovine serum albumin, cardiolipin, dendritic cells, leukotriene C4, lipid A, lipopolysaccharide, platelet activating factor, poly(U)RNA, BAY-u9773, CD40, CTSG, ELANE, F10, F2R, GNLY, IFNG, Lethal toxin, NFkB, PLAU, Pkc, SARM1, SP600125, TGFB1, TNFRSF12A, infection, mononuclear cells, nifedipine, troglitazone, verlukast, 15-deoxy-delta-12,14 -PGJ 2, A52, BGN, C1q (Complement Complex1q), CCL11, CSF2, CpG ODN 2006, CpG oligonucleotide, E. coli B5 lipopolysaccharide, ESR1, F. tularensis Schu4, FGF2, Francisella tularensis, GAPDH (includes EG:2597), GW9662, HIV, IFNA2, IL17A (includes EG:3605), IL18, IL22, IL2RB, IL4, IL6, Il12, Influenza A virus, LEF, LY294002, NOX4, Napc2, ODN 2006c, PLAUR, PROC, PRR, Pseudomonas aeruginosa, RNASE1, Rnase A, Ro31-8220, SERPINC1, SLIGKV-NH2, STAT4, Seb, Staphylococcus aureus, TLR3, Tnf, W7, Zaire ebolavirus, amlodipine, beta-estradiol, binding, bisphenol A, burn, calphostin C, cholecalciferol, ciglitazone, curcumin, cyclosporin A, ethanol, fibroblasts, genistein, macrophages, natural killer cells, nonylphenol, pirinixic acid, plasmacytoid dendritic cells, pyrrolidine dithiocarbamate, tyrphostin "
secretion regulated by (183)
"L-homocysteine, IL1B, lipopolysaccharide, Core, PRTN3, TNF, poly rI:rC-RNA, beta-estradiol, deprivation, IFNG, IL6, (E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexeneamide, PSMD4, S-nitrosoglutathione, TNFSF12, Zaire ebolavirus, progesterone, retinoic acid, AGT, AKT1, ATP-gamma-S, Bacille Calmette-Guerin, E1, E2, IL15, TREM1, diphenyleneiodonium, CP-55940, CXCL12, Cd3, Fibrinogen, Francisella tularensis subsp. holarctica LVS, HIV-1, IL2RB, IL33, LPNA, N-acetyl-L-cysteine, Ompa, PEG-SOD, PGF, TNFRSF8, U73122, catalase-polyethylene glycol, infection, insulin-dependent diabetes mellitus, troglitazone, 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine, 15-deoxy-delta-12,14 -PGJ 2, 3-hydroxyanthranilic acid, 4-(2-aminoethyl)benzenesulfonylfluoride, 6-amino-4-(4-phenoxyphenylethylamino)quinazoline, ADIPOQ, AKAP13, APP, BMP6, BMP7, CCL2, CCL3, CCR5, CD4, CD40, CNR2, CXCR4, DAP12-COUPLED RECEPTOR, DNA fragment, ENV, F2, F2RL1, Flagellin, HIV-1 strain BaL, HMGB1 (includes EG:3146), ICAM3, IL13, IL1A, IL4, IL6R, ITGB1, Igg2, L-165041, LPAR1, LY294002, MALP-2s, MAP3K7, Mapk, NFKBIA, OSM, PBMC cells, PD98059, Pam3-Cys-Ser-Lys4, Ro31-8220, S100A1, S100A8, S100A9, S100B, SB203580, SP600125, SPN, T lymphocytes, TGFB1, TLR2, TLR3, TLR7, TLR9, TNFRSF1A, TSLP, Tcr, Tlr, U0126, W7, actinomycin D, activation, alpha 1-antitrypsin Portland, binding, calphostin C, cholecalciferol, ciglitazone, curcumin, dendritic cells, dimethyl sulfoxide, forskolin, lipoteichoic acid, lysophosphatidic acid, mechanical strain, microglia, oxidative stress, oxophenylarsine, p85, pirinixic acid, protein-protein complex, puromycin, pyrrolidine dithiocarbamate, replication, rosiglitazone, smooth muscle cells, sphingosine-1-phosphate, stimulation, tempol "
release regulated by (116)
"IL1B, TNF, E. coli B5 lipopolysaccharide, lipopolysaccharide, Ebola virus, F2, IFNG, infection, monocyte-derived dendritic cells, BMP7, LDL, TAT, activation, FCR, HMGB1 (includes EG:3146), KNG1 (includes EG:3827), immune, mast cells, C5, Collagen Type I, DDR1, Francisella tularensis subsp. holarctica LVS, ML 120B, NFkB, P38 MAPK, PS-1145, Pam3-Cys-Ser-Lys4, TLR3, Zaire ebolavirus, lipoteichoic acid, methylprednisolone, poly rI:rC-RNA, 19-(p-fluorophenoxy)-resolvin E1 methyl ester, AGT, AP-1, BDKRB1, BDKRB2, C3, CSF1, CSF2, Cytokine, F2RL1, Filoviridae, IFNK, IL10, IL17A (includes EG:3605), IL4, IL6, IL6 RECEPTOR, IL8, Il1, Il6, L-cysteine, L-homocystine, L-methionine, LTA, LTB, Marburg virus, OSCAR, PD98059, SB203580, SOCS1, SOCS3, TLR4, TLR7, TLR9, TNFSF14, TREM1, YOPH, Yersinia pestis endotoxin, bisindolylmaleimide I, blood platelets, ciglitazone, degranulation, dexamethasone, experimentally induced bacterial peritonitis, genistein, herbimycin, homocysteine, interaction, leukotriene B4, lipoxin A4, macrophages, metformin, natural killer cells, pioglitazone, protein, troglitazone "
induction regulated by (38)
"activation, dendritic cells, Tlr, fibroblasts, plasmacytoid dendritic cells, IFIH1, IKBKE, RARRES3, TBK1, E. coli lipopolysaccharide, IL18, IFNB1, IL17A (includes EG:3605), IL1B, IRAK4, ITGAM, Il1, Influenza A virus, Influenza B virus, Influenza C virus, Interferon Alpha, Pam3-cys, Porphyromonas gingivalis lipopolysaccharide, TIRAP, TNF, Tnf, cycloheximide, poly rI:rC-RNA, shear stress "
binding regulated by (25)
"NSC 651016, WAS, D-glucose, DARC, IFNG, plerixafor, CCL11, CSF1, CXCR4, IRF3, P38 MAPK, Vckbp3, acidic pH stimulus, retinoic acid, rosiglitazone "
upregulation regulated by (22)
"Yersinia enterocolitica, bacteria, ALB, AGER, Ebola virus, PD98059, TLR4, inflammatory stimulus "
localization regulated by (21)
"steroid, lipopolysaccharide, candesartan, corticosteroid, felodipine, rosiglitazone, 12-3-adamantane-1-yl-ureido-dodecanoic acid n-butyl ester, DARC, IL17A (includes EG:3605), PECAM1, TLR4, cecal ligation and perforation, cerivastatin, simvastatin, troglitazone "
synthesis regulated by (8)
"MAP2K6, TNF, 1-palmitoyl-2-(epoxycyclopentenone)-sn-glycero-3-phosphorylcholine, 1-palmitoyl-2-(epoxyisoprostane)-sn-glycero-3-phosphorylcholine, CALCA, FCER1G, FCGR1A, IL10, NFkB, f(ab')2 fragment, nickel chloride "
activation regulated by (6)
"ETS1, Escherichia coli 2348/69, F2R, FliC, NFkB, PROC, STAT1, STAT6, TNF "
transcription regulated by (6)
"CAMP, IL1B, EP300, Erk1/2, Histone h3, Ikb, N-Ac-Leu-Leu-norleucinal, N-terminal domain, NFkB, P38 MAPK, Sb202190, tosylphenylalanyl chloromethyl ketone "
translocation regulated by (4)
"TLR4, TYROBP "
activity regulated by (3)
"Chemokine, L-homocysteine, Vckbp3, heparin "
degradation regulated by (3)
"CCBP2, Mmp "
internalization regulated by (3)
"CCBP2, endothelial cells "
concentration regulated by (2)
"congenital ureteropelvic junction obstruction, infection "
generation regulated by (2)
"IL4, dodecyl fatty alcohol phosphate, lysophosphatidic acid "
regulation regulated by (2)
"KLF2, NFkB, cerivastatin "
stabilization regulated by (2)
"PD98059, SB203580, TNF "
accumulation regulated by (1)
IL1B
elaboration regulated by (1)
"IL13, pegademase bovine "
excretion regulated by (1)
"congenital ureteropelvic junction obstruction, surgery "
function regulated by (1)
CCR2
inhibition regulated by (1)
m007R
shedding regulated by (1)
Mmp
translation regulated by (1)
ionizing radiation
-
Chemical Regulation
expression regulated by (654)
"TNF, lipopolysaccharide, IL1B, IFNG, CP-55940, NFkB, IL6, prostaglandin E2, IL1A, FN1, HGF, F2, PD98059, integrin binding domain, CD40LG, FAS, Ifn gamma, PD 168393, PGF, TAT, beta-estradiol, cerivastatin, negative pressure, nickel chloride, retinoic acid, BMP7, NR3C1, PLG, U0126, binding, endometrial stromal cells, infection, protein fragment, IKBKB, IL13, IL6R, Il1, KLF2, LPL, NfkB1-RelA, Rlp, TGFA, idiopathic pulmonary fibrosis, phytohemagglutinin, rosiglitazone, 15-deoxy-delta-12,14 -PGJ 2, APP, CD40, CNR2, Immunoglobulin, L-homocysteine, SB203580, SR 144528, Sb202190, TNFRSF1A, benzyloxycarbonyl-Leu-Leu-Leu aldehyde, cycloheximide, lymphocytic choriomeningitis virus, mechanical strain, peptidoglycan, phorbol myristate acetate, shear stress, steroid, wortmannin, EGFR, IFNB1, IL1RN, JUN, Jnk, KITLG, LDL, LY294002, N-formyl-Met-Leu-Phe, NFKBIA, PDGF-BB, PLP1, RELA, Rac, STAT3, TNFSF12, VEGFA, [D-Ala2,N-Me-Phe4,Gly5-ol]-Enkephalin, adhesion, amphotericin B, apoptosis, dexamethasone, neutrophils, poly rI:rC-RNA, progesterone, 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine, ADCYAP1, ADIPOQ, AGI-1067, AIMP1, Bacillus anthracis Sterne strain 7702, C5, CAMP, CCBP2, CCL11, CCL3, CCL4, CCL5, COL1A1, CXCL12, D609, DARC, DNA fragment, E. coli lipopolysaccharide, Ebola virus, F. tularensis novicida U112, FOS, FXYD5, Fc epsilon r1, Francisella tularensis live vaccine strain lipopolysaccharide, GJA1, GSK3B, Gliadin, HAEC cells, HMGB1 (includes EG:3146), I Kappa B Alpha, IDN-1529, IFNA2, ITGB1, JAK1, Jnk-binding domain, LEF, Listeria monocytogenes 10403S, NFKB1, NOS3, NfkB-RelA, PF4, PLA2G10, PPARG, PROC, Pertussis toxin, RET, RGS10, S-nitrosoglutathione, SARS coronavirus HKU-39849, SMARCA4, SP600125, STAT4, Salmonella, Sendai virus, Stx2, TGFB1, TLR3, TNFSF11, VIP, camobucol, cilostazol, corticosteroid, diphenyleneiodonium, estrogen, experimentally-induced asthma, heavy metal, histamine, hyaluronic acid, hypoxia, ilomastat, isopentenyl diphosphate, lactacystin, maturation, n-3 fatty acids, piceatannol, poly-L-lysine, probucol, protein-protein complex, simvastatin, troglitazone, zVAD-FMK, 1,2-dipalmitoylphosphatidylcholine, 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine, 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphorylcholine, 2-(2-[4-phenoxy-2-propylphenoxy]ethyl)indole-5-acetic acid, 5-N-ethylcarboxamido adenosine, 5/6-nephrectomy, ADORA1, AG490, AGT, AKT1, ALB, AP-1, ATP-gamma-S, Angiotensin II receptor type 1, B lymphocytes, BAY 11-7085, Bacillus anthracis, C3, CD28, CDKN1A, CHUK, COL18A1, CSF2, CXCL3, CXCR4, Cd3, Collagen Type IV, D-glucose, D-homocysteine, DEFENSIN, E-64c, EGR1, ERBB4, Enterotoxin B, Erk1/2, Esat6, F2R, F2RL1, FASLG, FCGR2A, Francisella tularensis subsp. holarctica LVS, Gd3+, Gpcr, Hcg (chorionic gonadotropin complex), Ht29 cells, IFI16, IL10, IL17F, IL18, IL3, IL4, IL9, INSR, IRF3, Iberiotoxin, Ifn, IgE, Igg, Insulin, KDM1A, L-alpha-lysophosphatidylcholine, palmitoyl, L-cysteine, L-homocystine, L-methionine, LEP, LIPG, LPNA, Laminin, MAP2K4, MAP2K6, MAPK1, MAPK14, MAPK8, MAPKAPK2, MEOX2, MYD88, N-Ac-Leu-Leu-norleucinal, N-nitro-L-arginine methyl ester, NFKBIB, NFKBIE, NLR, Nfat, OLR1, PAGA, PBMC cells, PP2/AG1879 tyrosine kinase inhibitor, PRTN3, PXO1 122, Pdgf protein, Pseudomonas aeruginosa, RETN, Rabies virus strain SPBNGAS-GAS, Raf, S-nitroso-N-acetyl-DL-penicillamine, S-nitroso-N-acetylpenicillamine, S100A8, S100A9, SELP, SELPLG, SERPINA1, SMAD3, SPP1, STAT1, STAT6, Streptococcus sp. group G, TLR2, TNFRSF12A, TRADD, TRAF6, TYROBP, Tc52, Tlr, Tnf, UCN2, VP35, YM 529, YOPH, ZNF217, alprazolam, apigenin, apocynin, atorvastatin, bisphenol A, camptothecin, carbaprostacyclin, cardiolipin, cardiotoxin, colchicine, cyclosporin A, cytochalasin D, decidualization, dendritic cells, dioleoyl phosphatidylethanolamine, disruption, edaravone, encephalomyocarditis virus, endometriosis, endothelial cells, entrance, epoxyquinol B, ethanol, geranylgeranyl pyrophosphate, glucocorticoid, homocysteine, human respiratory syncytial virus A2, hydrocortisone, hydrogen peroxide, hydroxyurea, inflammation, injury, medroxyprogesterone acetate, mevalonic acid, migration, monocyte-derived dendritic cells, myeloid dendritic cells, nonylphenol, omega-6 polyunsaturated fatty acid, omega-9 fatty acid, omega-N-methylarginine, orlistat, oxypurinol, peripheral blood monocytes, phagocytosis, phorbol esters, pirinixic acid, polyinosinic acid, prednisolone, respiratory syncytial virus, resveratrol, salsalate, silica, stimulation, stromal cells, tosylphenylalanyl chloromethyl ketone, unmethylated CpG ODN, wounding, zidovudine "
production regulated by (227)
"PRTN3, homocysteine, Ebola virus, poly rI:rC-RNA, IL1B, IL2, IL15, CAMP, F2, Igg, Marburg virus, TNF, Bacillus anthracis, C3, C5, SB203580, TNFSF12, IL10, IL1A, activation, amphotericin B, leukotriene D4, CD40LG, CpG ODN 1826, Cytokine, E. coli lipopolysaccharide, FK 156, FK 565, Francisella tularensis live vaccine strain lipopolysaccharide, IL6R, N-acetylmuramyl-L-alanyl-D-isoglutamine, PD98059, PTAFR, RNASE2, S-(2, 3-bispalmitoyloxypropyl)-cysteine-GDPKHPKSF, TLR4, Tlr, Tnfsf5, U0126, U73122, advanced glycation endproducts-bovine serum albumin, cardiolipin, dendritic cells, leukotriene C4, lipid A, lipopolysaccharide, platelet activating factor, poly(U)RNA, BAY-u9773, CD40, CTSG, ELANE, F10, F2R, GNLY, IFNG, Lethal toxin, NFkB, PLAU, Pkc, SARM1, SP600125, TGFB1, TNFRSF12A, infection, mononuclear cells, nifedipine, troglitazone, verlukast, 15-deoxy-delta-12,14 -PGJ 2, A52, BGN, C1q (Complement Complex1q), CCL11, CSF2, CpG ODN 2006, CpG oligonucleotide, E. coli B5 lipopolysaccharide, ESR1, F. tularensis Schu4, FGF2, Francisella tularensis, GAPDH (includes EG:2597), GW9662, HIV, IFNA2, IL17A (includes EG:3605), IL18, IL22, IL2RB, IL4, IL6, Il12, Influenza A virus, LEF, LY294002, NOX4, Napc2, ODN 2006c, PLAUR, PROC, PRR, Pseudomonas aeruginosa, RNASE1, Rnase A, Ro31-8220, SERPINC1, SLIGKV-NH2, STAT4, Seb, Staphylococcus aureus, TLR3, Tnf, W7, Zaire ebolavirus, amlodipine, beta-estradiol, binding, bisphenol A, burn, calphostin C, cholecalciferol, ciglitazone, curcumin, cyclosporin A, ethanol, fibroblasts, genistein, macrophages, natural killer cells, nonylphenol, pirinixic acid, plasmacytoid dendritic cells, pyrrolidine dithiocarbamate, tyrphostin "
secretion regulated by (183)
"L-homocysteine, IL1B, lipopolysaccharide, Core, PRTN3, TNF, poly rI:rC-RNA, beta-estradiol, deprivation, IFNG, IL6, (E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexeneamide, PSMD4, S-nitrosoglutathione, TNFSF12, Zaire ebolavirus, progesterone, retinoic acid, AGT, AKT1, ATP-gamma-S, Bacille Calmette-Guerin, E1, E2, IL15, TREM1, diphenyleneiodonium, CP-55940, CXCL12, Cd3, Fibrinogen, Francisella tularensis subsp. holarctica LVS, HIV-1, IL2RB, IL33, LPNA, N-acetyl-L-cysteine, Ompa, PEG-SOD, PGF, TNFRSF8, U73122, catalase-polyethylene glycol, infection, insulin-dependent diabetes mellitus, troglitazone, 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine, 15-deoxy-delta-12,14 -PGJ 2, 3-hydroxyanthranilic acid, 4-(2-aminoethyl)benzenesulfonylfluoride, 6-amino-4-(4-phenoxyphenylethylamino)quinazoline, ADIPOQ, AKAP13, APP, BMP6, BMP7, CCL2, CCL3, CCR5, CD4, CD40, CNR2, CXCR4, DAP12-COUPLED RECEPTOR, DNA fragment, ENV, F2, F2RL1, Flagellin, HIV-1 strain BaL, HMGB1 (includes EG:3146), ICAM3, IL13, IL1A, IL4, IL6R, ITGB1, Igg2, L-165041, LPAR1, LY294002, MALP-2s, MAP3K7, Mapk, NFKBIA, OSM, PBMC cells, PD98059, Pam3-Cys-Ser-Lys4, Ro31-8220, S100A1, S100A8, S100A9, S100B, SB203580, SP600125, SPN, T lymphocytes, TGFB1, TLR2, TLR3, TLR7, TLR9, TNFRSF1A, TSLP, Tcr, Tlr, U0126, W7, actinomycin D, activation, alpha 1-antitrypsin Portland, binding, calphostin C, cholecalciferol, ciglitazone, curcumin, dendritic cells, dimethyl sulfoxide, forskolin, lipoteichoic acid, lysophosphatidic acid, mechanical strain, microglia, oxidative stress, oxophenylarsine, p85, pirinixic acid, protein-protein complex, puromycin, pyrrolidine dithiocarbamate, replication, rosiglitazone, smooth muscle cells, sphingosine-1-phosphate, stimulation, tempol "
release regulated by (116)
"IL1B, TNF, E. coli B5 lipopolysaccharide, lipopolysaccharide, Ebola virus, F2, IFNG, infection, monocyte-derived dendritic cells, BMP7, LDL, TAT, activation, FCR, HMGB1 (includes EG:3146), KNG1 (includes EG:3827), immune, mast cells, C5, Collagen Type I, DDR1, Francisella tularensis subsp. holarctica LVS, ML 120B, NFkB, P38 MAPK, PS-1145, Pam3-Cys-Ser-Lys4, TLR3, Zaire ebolavirus, lipoteichoic acid, methylprednisolone, poly rI:rC-RNA, 19-(p-fluorophenoxy)-resolvin E1 methyl ester, AGT, AP-1, BDKRB1, BDKRB2, C3, CSF1, CSF2, Cytokine, F2RL1, Filoviridae, IFNK, IL10, IL17A (includes EG:3605), IL4, IL6, IL6 RECEPTOR, IL8, Il1, Il6, L-cysteine, L-homocystine, L-methionine, LTA, LTB, Marburg virus, OSCAR, PD98059, SB203580, SOCS1, SOCS3, TLR4, TLR7, TLR9, TNFSF14, TREM1, YOPH, Yersinia pestis endotoxin, bisindolylmaleimide I, blood platelets, ciglitazone, degranulation, dexamethasone, experimentally induced bacterial peritonitis, genistein, herbimycin, homocysteine, interaction, leukotriene B4, lipoxin A4, macrophages, metformin, natural killer cells, pioglitazone, protein, troglitazone "
induction regulated by (38)
"activation, dendritic cells, Tlr, fibroblasts, plasmacytoid dendritic cells, IFIH1, IKBKE, RARRES3, TBK1, E. coli lipopolysaccharide, IL18, IFNB1, IL17A (includes EG:3605), IL1B, IRAK4, ITGAM, Il1, Influenza A virus, Influenza B virus, Influenza C virus, Interferon Alpha, Pam3-cys, Porphyromonas gingivalis lipopolysaccharide, TIRAP, TNF, Tnf, cycloheximide, poly rI:rC-RNA, shear stress "
binding regulated by (25)
"NSC 651016, WAS, D-glucose, DARC, IFNG, plerixafor, CCL11, CSF1, CXCR4, IRF3, P38 MAPK, Vckbp3, acidic pH stimulus, retinoic acid, rosiglitazone "
upregulation regulated by (22)
"Yersinia enterocolitica, bacteria, ALB, AGER, Ebola virus, PD98059, TLR4, inflammatory stimulus "
localization regulated by (21)
"steroid, lipopolysaccharide, candesartan, corticosteroid, felodipine, rosiglitazone, 12-3-adamantane-1-yl-ureido-dodecanoic acid n-butyl ester, DARC, IL17A (includes EG:3605), PECAM1, TLR4, cecal ligation and perforation, cerivastatin, simvastatin, troglitazone "
synthesis regulated by (8)
"MAP2K6, TNF, 1-palmitoyl-2-(epoxycyclopentenone)-sn-glycero-3-phosphorylcholine, 1-palmitoyl-2-(epoxyisoprostane)-sn-glycero-3-phosphorylcholine, CALCA, FCER1G, FCGR1A, IL10, NFkB, f(ab')2 fragment, nickel chloride "
activation regulated by (6)
"ETS1, Escherichia coli 2348/69, F2R, FliC, NFkB, PROC, STAT1, STAT6, TNF "
transcription regulated by (6)
"CAMP, IL1B, EP300, Erk1/2, Histone h3, Ikb, N-Ac-Leu-Leu-norleucinal, N-terminal domain, NFkB, P38 MAPK, Sb202190, tosylphenylalanyl chloromethyl ketone "
translocation regulated by (4)
"TLR4, TYROBP "
activity regulated by (3)
"Chemokine, L-homocysteine, Vckbp3, heparin "
degradation regulated by (3)
"CCBP2, Mmp "
internalization regulated by (3)
"CCBP2, endothelial cells "
concentration regulated by (2)
"congenital ureteropelvic junction obstruction, infection "
generation regulated by (2)
"IL4, dodecyl fatty alcohol phosphate, lysophosphatidic acid "
regulation regulated by (2)
"KLF2, NFkB, cerivastatin "
stabilization regulated by (2)
"PD98059, SB203580, TNF "
accumulation regulated by (1)
IL1B
elaboration regulated by (1)
"IL13, pegademase bovine "
excretion regulated by (1)
"congenital ureteropelvic junction obstruction, surgery "
function regulated by (1)
CCR2
inhibition regulated by (1)
m007R
shedding regulated by (1)
Mmp
translation regulated by (1)
ionizing radiation
-
Process Regulation
expression regulated by (654)
"TNF, lipopolysaccharide, IL1B, IFNG, CP-55940, NFkB, IL6, prostaglandin E2, IL1A, FN1, HGF, F2, PD98059, integrin binding domain, CD40LG, FAS, Ifn gamma, PD 168393, PGF, TAT, beta-estradiol, cerivastatin, negative pressure, nickel chloride, retinoic acid, BMP7, NR3C1, PLG, U0126, binding, endometrial stromal cells, infection, protein fragment, IKBKB, IL13, IL6R, Il1, KLF2, LPL, NfkB1-RelA, Rlp, TGFA, idiopathic pulmonary fibrosis, phytohemagglutinin, rosiglitazone, 15-deoxy-delta-12,14 -PGJ 2, APP, CD40, CNR2, Immunoglobulin, L-homocysteine, SB203580, SR 144528, Sb202190, TNFRSF1A, benzyloxycarbonyl-Leu-Leu-Leu aldehyde, cycloheximide, lymphocytic choriomeningitis virus, mechanical strain, peptidoglycan, phorbol myristate acetate, shear stress, steroid, wortmannin, EGFR, IFNB1, IL1RN, JUN, Jnk, KITLG, LDL, LY294002, N-formyl-Met-Leu-Phe, NFKBIA, PDGF-BB, PLP1, RELA, Rac, STAT3, TNFSF12, VEGFA, [D-Ala2,N-Me-Phe4,Gly5-ol]-Enkephalin, adhesion, amphotericin B, apoptosis, dexamethasone, neutrophils, poly rI:rC-RNA, progesterone, 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine, ADCYAP1, ADIPOQ, AGI-1067, AIMP1, Bacillus anthracis Sterne strain 7702, C5, CAMP, CCBP2, CCL11, CCL3, CCL4, CCL5, COL1A1, CXCL12, D609, DARC, DNA fragment, E. coli lipopolysaccharide, Ebola virus, F. tularensis novicida U112, FOS, FXYD5, Fc epsilon r1, Francisella tularensis live vaccine strain lipopolysaccharide, GJA1, GSK3B, Gliadin, HAEC cells, HMGB1 (includes EG:3146), I Kappa B Alpha, IDN-1529, IFNA2, ITGB1, JAK1, Jnk-binding domain, LEF, Listeria monocytogenes 10403S, NFKB1, NOS3, NfkB-RelA, PF4, PLA2G10, PPARG, PROC, Pertussis toxin, RET, RGS10, S-nitrosoglutathione, SARS coronavirus HKU-39849, SMARCA4, SP600125, STAT4, Salmonella, Sendai virus, Stx2, TGFB1, TLR3, TNFSF11, VIP, camobucol, cilostazol, corticosteroid, diphenyleneiodonium, estrogen, experimentally-induced asthma, heavy metal, histamine, hyaluronic acid, hypoxia, ilomastat, isopentenyl diphosphate, lactacystin, maturation, n-3 fatty acids, piceatannol, poly-L-lysine, probucol, protein-protein complex, simvastatin, troglitazone, zVAD-FMK, 1,2-dipalmitoylphosphatidylcholine, 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine, 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphorylcholine, 2-(2-[4-phenoxy-2-propylphenoxy]ethyl)indole-5-acetic acid, 5-N-ethylcarboxamido adenosine, 5/6-nephrectomy, ADORA1, AG490, AGT, AKT1, ALB, AP-1, ATP-gamma-S, Angiotensin II receptor type 1, B lymphocytes, BAY 11-7085, Bacillus anthracis, C3, CD28, CDKN1A, CHUK, COL18A1, CSF2, CXCL3, CXCR4, Cd3, Collagen Type IV, D-glucose, D-homocysteine, DEFENSIN, E-64c, EGR1, ERBB4, Enterotoxin B, Erk1/2, Esat6, F2R, F2RL1, FASLG, FCGR2A, Francisella tularensis subsp. holarctica LVS, Gd3+, Gpcr, Hcg (chorionic gonadotropin complex), Ht29 cells, IFI16, IL10, IL17F, IL18, IL3, IL4, IL9, INSR, IRF3, Iberiotoxin, Ifn, IgE, Igg, Insulin, KDM1A, L-alpha-lysophosphatidylcholine, palmitoyl, L-cysteine, L-homocystine, L-methionine, LEP, LIPG, LPNA, Laminin, MAP2K4, MAP2K6, MAPK1, MAPK14, MAPK8, MAPKAPK2, MEOX2, MYD88, N-Ac-Leu-Leu-norleucinal, N-nitro-L-arginine methyl ester, NFKBIB, NFKBIE, NLR, Nfat, OLR1, PAGA, PBMC cells, PP2/AG1879 tyrosine kinase inhibitor, PRTN3, PXO1 122, Pdgf protein, Pseudomonas aeruginosa, RETN, Rabies virus strain SPBNGAS-GAS, Raf, S-nitroso-N-acetyl-DL-penicillamine, S-nitroso-N-acetylpenicillamine, S100A8, S100A9, SELP, SELPLG, SERPINA1, SMAD3, SPP1, STAT1, STAT6, Streptococcus sp. group G, TLR2, TNFRSF12A, TRADD, TRAF6, TYROBP, Tc52, Tlr, Tnf, UCN2, VP35, YM 529, YOPH, ZNF217, alprazolam, apigenin, apocynin, atorvastatin, bisphenol A, camptothecin, carbaprostacyclin, cardiolipin, cardiotoxin, colchicine, cyclosporin A, cytochalasin D, decidualization, dendritic cells, dioleoyl phosphatidylethanolamine, disruption, edaravone, encephalomyocarditis virus, endometriosis, endothelial cells, entrance, epoxyquinol B, ethanol, geranylgeranyl pyrophosphate, glucocorticoid, homocysteine, human respiratory syncytial virus A2, hydrocortisone, hydrogen peroxide, hydroxyurea, inflammation, injury, medroxyprogesterone acetate, mevalonic acid, migration, monocyte-derived dendritic cells, myeloid dendritic cells, nonylphenol, omega-6 polyunsaturated fatty acid, omega-9 fatty acid, omega-N-methylarginine, orlistat, oxypurinol, peripheral blood monocytes, phagocytosis, phorbol esters, pirinixic acid, polyinosinic acid, prednisolone, respiratory syncytial virus, resveratrol, salsalate, silica, stimulation, stromal cells, tosylphenylalanyl chloromethyl ketone, unmethylated CpG ODN, wounding, zidovudine "
production regulated by (227)
"PRTN3, homocysteine, Ebola virus, poly rI:rC-RNA, IL1B, IL2, IL15, CAMP, F2, Igg, Marburg virus, TNF, Bacillus anthracis, C3, C5, SB203580, TNFSF12, IL10, IL1A, activation, amphotericin B, leukotriene D4, CD40LG, CpG ODN 1826, Cytokine, E. coli lipopolysaccharide, FK 156, FK 565, Francisella tularensis live vaccine strain lipopolysaccharide, IL6R, N-acetylmuramyl-L-alanyl-D-isoglutamine, PD98059, PTAFR, RNASE2, S-(2, 3-bispalmitoyloxypropyl)-cysteine-GDPKHPKSF, TLR4, Tlr, Tnfsf5, U0126, U73122, advanced glycation endproducts-bovine serum albumin, cardiolipin, dendritic cells, leukotriene C4, lipid A, lipopolysaccharide, platelet activating factor, poly(U)RNA, BAY-u9773, CD40, CTSG, ELANE, F10, F2R, GNLY, IFNG, Lethal toxin, NFkB, PLAU, Pkc, SARM1, SP600125, TGFB1, TNFRSF12A, infection, mononuclear cells, nifedipine, troglitazone, verlukast, 15-deoxy-delta-12,14 -PGJ 2, A52, BGN, C1q (Complement Complex1q), CCL11, CSF2, CpG ODN 2006, CpG oligonucleotide, E. coli B5 lipopolysaccharide, ESR1, F. tularensis Schu4, FGF2, Francisella tularensis, GAPDH (includes EG:2597), GW9662, HIV, IFNA2, IL17A (includes EG:3605), IL18, IL22, IL2RB, IL4, IL6, Il12, Influenza A virus, LEF, LY294002, NOX4, Napc2, ODN 2006c, PLAUR, PROC, PRR, Pseudomonas aeruginosa, RNASE1, Rnase A, Ro31-8220, SERPINC1, SLIGKV-NH2, STAT4, Seb, Staphylococcus aureus, TLR3, Tnf, W7, Zaire ebolavirus, amlodipine, beta-estradiol, binding, bisphenol A, burn, calphostin C, cholecalciferol, ciglitazone, curcumin, cyclosporin A, ethanol, fibroblasts, genistein, macrophages, natural killer cells, nonylphenol, pirinixic acid, plasmacytoid dendritic cells, pyrrolidine dithiocarbamate, tyrphostin "
secretion regulated by (183)
"L-homocysteine, IL1B, lipopolysaccharide, Core, PRTN3, TNF, poly rI:rC-RNA, beta-estradiol, deprivation, IFNG, IL6, (E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexeneamide, PSMD4, S-nitrosoglutathione, TNFSF12, Zaire ebolavirus, progesterone, retinoic acid, AGT, AKT1, ATP-gamma-S, Bacille Calmette-Guerin, E1, E2, IL15, TREM1, diphenyleneiodonium, CP-55940, CXCL12, Cd3, Fibrinogen, Francisella tularensis subsp. holarctica LVS, HIV-1, IL2RB, IL33, LPNA, N-acetyl-L-cysteine, Ompa, PEG-SOD, PGF, TNFRSF8, U73122, catalase-polyethylene glycol, infection, insulin-dependent diabetes mellitus, troglitazone, 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine, 15-deoxy-delta-12,14 -PGJ 2, 3-hydroxyanthranilic acid, 4-(2-aminoethyl)benzenesulfonylfluoride, 6-amino-4-(4-phenoxyphenylethylamino)quinazoline, ADIPOQ, AKAP13, APP, BMP6, BMP7, CCL2, CCL3, CCR5, CD4, CD40, CNR2, CXCR4, DAP12-COUPLED RECEPTOR, DNA fragment, ENV, F2, F2RL1, Flagellin, HIV-1 strain BaL, HMGB1 (includes EG:3146), ICAM3, IL13, IL1A, IL4, IL6R, ITGB1, Igg2, L-165041, LPAR1, LY294002, MALP-2s, MAP3K7, Mapk, NFKBIA, OSM, PBMC cells, PD98059, Pam3-Cys-Ser-Lys4, Ro31-8220, S100A1, S100A8, S100A9, S100B, SB203580, SP600125, SPN, T lymphocytes, TGFB1, TLR2, TLR3, TLR7, TLR9, TNFRSF1A, TSLP, Tcr, Tlr, U0126, W7, actinomycin D, activation, alpha 1-antitrypsin Portland, binding, calphostin C, cholecalciferol, ciglitazone, curcumin, dendritic cells, dimethyl sulfoxide, forskolin, lipoteichoic acid, lysophosphatidic acid, mechanical strain, microglia, oxidative stress, oxophenylarsine, p85, pirinixic acid, protein-protein complex, puromycin, pyrrolidine dithiocarbamate, replication, rosiglitazone, smooth muscle cells, sphingosine-1-phosphate, stimulation, tempol "
release regulated by (116)
"IL1B, TNF, E. coli B5 lipopolysaccharide, lipopolysaccharide, Ebola virus, F2, IFNG, infection, monocyte-derived dendritic cells, BMP7, LDL, TAT, activation, FCR, HMGB1 (includes EG:3146), KNG1 (includes EG:3827), immune, mast cells, C5, Collagen Type I, DDR1, Francisella tularensis subsp. holarctica LVS, ML 120B, NFkB, P38 MAPK, PS-1145, Pam3-Cys-Ser-Lys4, TLR3, Zaire ebolavirus, lipoteichoic acid, methylprednisolone, poly rI:rC-RNA, 19-(p-fluorophenoxy)-resolvin E1 methyl ester, AGT, AP-1, BDKRB1, BDKRB2, C3, CSF1, CSF2, Cytokine, F2RL1, Filoviridae, IFNK, IL10, IL17A (includes EG:3605), IL4, IL6, IL6 RECEPTOR, IL8, Il1, Il6, L-cysteine, L-homocystine, L-methionine, LTA, LTB, Marburg virus, OSCAR, PD98059, SB203580, SOCS1, SOCS3, TLR4, TLR7, TLR9, TNFSF14, TREM1, YOPH, Yersinia pestis endotoxin, bisindolylmaleimide I, blood platelets, ciglitazone, degranulation, dexamethasone, experimentally induced bacterial peritonitis, genistein, herbimycin, homocysteine, interaction, leukotriene B4, lipoxin A4, macrophages, metformin, natural killer cells, pioglitazone, protein, troglitazone "
induction regulated by (38)
"activation, dendritic cells, Tlr, fibroblasts, plasmacytoid dendritic cells, IFIH1, IKBKE, RARRES3, TBK1, E. coli lipopolysaccharide, IL18, IFNB1, IL17A (includes EG:3605), IL1B, IRAK4, ITGAM, Il1, Influenza A virus, Influenza B virus, Influenza C virus, Interferon Alpha, Pam3-cys, Porphyromonas gingivalis lipopolysaccharide, TIRAP, TNF, Tnf, cycloheximide, poly rI:rC-RNA, shear stress "
binding regulated by (25)
"NSC 651016, WAS, D-glucose, DARC, IFNG, plerixafor, CCL11, CSF1, CXCR4, IRF3, P38 MAPK, Vckbp3, acidic pH stimulus, retinoic acid, rosiglitazone "
upregulation regulated by (22)
"Yersinia enterocolitica, bacteria, ALB, AGER, Ebola virus, PD98059, TLR4, inflammatory stimulus "
localization regulated by (21)
"steroid, lipopolysaccharide, candesartan, corticosteroid, felodipine, rosiglitazone, 12-3-adamantane-1-yl-ureido-dodecanoic acid n-butyl ester, DARC, IL17A (includes EG:3605), PECAM1, TLR4, cecal ligation and perforation, cerivastatin, simvastatin, troglitazone "
synthesis regulated by (8)
"MAP2K6, TNF, 1-palmitoyl-2-(epoxycyclopentenone)-sn-glycero-3-phosphorylcholine, 1-palmitoyl-2-(epoxyisoprostane)-sn-glycero-3-phosphorylcholine, CALCA, FCER1G, FCGR1A, IL10, NFkB, f(ab')2 fragment, nickel chloride "
activation regulated by (6)
"ETS1, Escherichia coli 2348/69, F2R, FliC, NFkB, PROC, STAT1, STAT6, TNF "
transcription regulated by (6)
"CAMP, IL1B, EP300, Erk1/2, Histone h3, Ikb, N-Ac-Leu-Leu-norleucinal, N-terminal domain, NFkB, P38 MAPK, Sb202190, tosylphenylalanyl chloromethyl ketone "
translocation regulated by (4)
"TLR4, TYROBP "
activity regulated by (3)
"Chemokine, L-homocysteine, Vckbp3, heparin "
degradation regulated by (3)
"CCBP2, Mmp "
internalization regulated by (3)
"CCBP2, endothelial cells "
concentration regulated by (2)
"congenital ureteropelvic junction obstruction, infection "
generation regulated by (2)
"IL4, dodecyl fatty alcohol phosphate, lysophosphatidic acid "
regulation regulated by (2)
"KLF2, NFkB, cerivastatin "
stabilization regulated by (2)
"PD98059, SB203580, TNF "
accumulation regulated by (1)
IL1B
elaboration regulated by (1)
"IL13, pegademase bovine "
excretion regulated by (1)
"congenital ureteropelvic junction obstruction, surgery "
function regulated by (1)
CCR2
inhibition regulated by (1)
m007R
shedding regulated by (1)
Mmp
translation regulated by (1)
ionizing radiation
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Gene Modification
molecular cleavage regulated by (11)
MMP2, Mmp, Beta tryptase, CMA1, DPP4, MMP1 (includes EG:4312), MMP14, MMP3, concanavalin a
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Biomarker Information
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Biomarker Information
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Drug Information
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Drug Information
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