Gene View: Havcr1 (Mammalian)

Mutation Information

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Mutation	Mutation Type	Disease Association	Supporting Evidence
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Show Findings (2)Hide Findings (2)
Unspecified	Gene Deletion	asthma	Show Findings (1)
Unspecified	Gene Deletion	atopic dermatitis	Show Findings (1)
A-1637G	Gene Substitution	rheumatoid arthritis	Show Findings (1)
A-2281G	Gene Substitution	asthma	Show Findings (1)
C2496	Gene Substitution	asthma	Show Findings (1)
Unspecified	Gene Substitution	asthma	Show Findings (1)

Protein Family, Domain

Location Information

Gene Regulation

Protein-Protein Interaction

Protein-Nucleic Acid Interaction

Protein-Cell Tissue Interaction

Protein-Microorganism Interaction

Disease Information

Disease Category	Specific Disease	Supporting Evidence
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Cancer	clear-cell adenocarcinoma	Show Findings (4)
Cancer	oxyphilic adenoma	Show Findings (2)
Cancer	papillary renal cell carcinoma	Show Findings (1)
Cardiovascular Disease	hypertension	Show Findings (1)
Cardiovascular Disease	Wegener's granulomatosis	Show Findings (1)
Dermatolocial Disorder	atopic dermatitis	Show Findings (1)
Dermatolocial Disorder	contact dermatitis	Show Findings (1)
Immunological Disease	rheumatoid arthritis	Show Findings (3)
Immunological Disease	experimental autoimmune encephalomyelitis	Show Findings (2)
Immunological Disease	immediate hypersensitivity	Show Findings (1)
Immunological Disease	atopic dermatitis	Show Findings (1)
Immunological Disease	contact dermatitis	Show Findings (1)
Inflammatory Disease	asthma	Show Findings (1)
Inflammatory Disease	Wegener's granulomatosis	Show Findings (1)
Neurological Disease	experimental autoimmune enephalomyelitis	Show Findings (1)
Neurological Disease	multiple sclerosis	Show Findings (1)
Renal or Urological Disorder	proteinuria	Show Findings (6)
Renal or Urological Disorder	renal disease	Show Findings (6)
Renal or Urological Disorder	ischemic acute renal failure	Show Findings (1)
Renal or Urological Disorder	chronic allograft nephropathy	Show Findings (1)
Renal or Urological Disorder	focal segmental glomerulosclerosis	Show Findings (1)
Respiratory Disease	asthma	Show Findings (1)

Molecular Process Information

Cellular Process Information

Organismal Process Information

Canonical Pathway

Pathway	Group	Pathway Category	Top Functions and Diseases
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ATM Signaling	Signaling Pathway	Cell Cycle Regulation, Cellular Stress and Injury	Cell Cycle; DNA Replication, Recombination, and Repair; Cell Death
Cell Cycle: G2/M DNA Damage Checkpoint Regulation	Signaling Pathway	Cancer, Disease-Specific Pathways	Cell Cycle; Cell Death; Cancer
Hereditary Breast Cancer Signaling	Signaling Pathway	Cancer, Disease-Specific Pathways	DNA Replication, Recombination, and Repair; Cell Cycle; Cancer
Ovarian Cancer Signaling	Signaling Pathway	Cancer, Disease-Specific Pathways	Cell Cycle; Cancer; Neurological Disease
Protein Ubiquitination Pathway	Signaling Pathway	Intracellular and Second Messenger Signaling	Cell-mediated Immune Response; Cellular Development; Cellular Function and maintanance
p53 Signaling	Tox List		Cell Cycle; Cell Death; Cellular Growth and Proliferation
p53 Signaling	Signaling Pathway	Cancer, Ingenuity Toxicity List Pathways	Cell Cycle; Cell Death; Cell-mediated Immune Response
Molecular Mechanisms of Cancer	Signaling Pathway	Cancer, Disease-Specific Pathways	Cell Cycle; Cell Death; Cellular Development
Role of BRCA1 in DNA Damage Response	Signaling Pathway	Cancer, Cellular Stress and Injury	DNA Replication, Recombination, and Repair; Cell Cycle; Cell Death
Role of CHK Proteins in Cell Cycle Checkpoint Control	Signaling Pathway	Cell Cycle Regulation, Cellular Stress and Injury	Cell Cycle; DNA Replication, Recombination, and Repair; Gene Expression
Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency	Signaling Pathway	Cellular Growth, Proliferation and Development, Organismal Growth and Development	Gene Expression; Organismal Development; Organ Development

Local Neighborhood (interaction network)

Transcriptional Regulators that Regulate Target

Molecule	Entrez Gene Name	Location	Molecule Type	Species	Supporting Evidence
HNF1A	HNF1 homeobox A			Human, rat, mouse	Show Findings (1)

Pathways and Mechanism

Molecule	Entrez Gene Name	Location	Type	Supporting Evidence
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CCND3	cyclin D3	Nucleus	other	Show Findings (2)
CD3		Plasma Membrane	complex	Show Findings (4)
CDK4	cyclin-dependent kinase 4	Nucleus	kinase	Show Findings (4)
CDK6	cyclin-dependent kinase 6	Nucleus	kinase	Show Findings (4)
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	Nucleus	other	Show Findings (2)
IFNG	interferon, gamma	Extracellular Space	cytokine	Show Findings (1)
lga		Plasma Membrane	complex	Show Findings (2)
IL10	interleukin 10	Extracellular Space	cytokine	Show Findings (2)
IL2	interleukin 2	Extracellular Space	cytokine	Show Findings (1)
IL2RA	interleukin 2 receptor, alpha	Plasma Membrane	transmembrane receptor	Show Findings (1)
IL4	interleukin 4	Extracellular Space	cytokine	Show Findings (2)
IL5	interleukin 5(colony-stimulating factor, eosinophil)	Extracellular Space	cytokine	Show Findings (1)
ITK	IL2-inducible T-cell kinase	Cytoplasm	kinase	Show Findings (4)
PI3K		Cytoplasm	complex	Show Findings (2)
TIMD4	T-cell immunoglobulin and mucin domain containing 4	Plasma Membrane	other	Show Findings (2)
TNF	tumor necrosisfactor (TNF superfamily, member 2)	Extracellular Space	cytokine	Show Findings (2)
UBQLN4	ubiquilin 4	Cytoplasm	other	Show Findings (2)
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	Plasma Membrane	kinase	Show Findings (4)

Drug Summary

Target Information

Pathways and Mechanism

Molecule	Entrez Gene Name	Location	Type	Supporting Evidence
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4-aminophenol		unknown	chemical - endogenous mammalian	Show Findings (2)
batimastat		unknown	chemical - protease inhibitor	Show Findings (4)
CD3		Plasma Membrane	complex	Show Findings (4)
cisplatin		unknown	chemical drug	Show Findings (4)
cyclosporin A		unknown	biologic drug	Show Findings (2)
D-serine		unknown	chemical - endogenous mammalian	Show Findings (1)
HNF1A	HNF1homeobox A	Nucleus	transcription regulator	Show Findings (2)
lga		Plasma Membrane	complex	Show Findings (2)
lge		Extracellular Space	complex	Show Findings (1)
ilomastat		unknown	chemical drug	Show Findings (1)
lipoate		unknown	chemical drug	Show Findings (2)
phorbol myristate acetate		unknown	chemical drug	Show Findings (1)
PTEN	phosphatase and tensin homolog	Cytoplasm	phosphatase	Show Findings (4)
ramipril		unknown	chemical drug	Show Findings (2)
REN2	renin 2tandem duplication of Ren1	Extracellular Space	peptidase	Show Findings (2)
sirolimus		unknown	chemical drug	Show Findings (2)
spironolactone		unknown	chemical drug	Show Findings (2)
TIMD4	T-cell immunoglobulin and mucin domain containing 4	Plasma Membrane	other	Show Findings (4)
UBQLN4	ubiquilin 4	Cytoplasm	other	Show Findings (2)

Drug Summary

Target Information

Top Reading List for Havcr1

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Supporting Literature

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